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Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging
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Hyperbaric Oxygen Therapy: Future Prospects in Regenerative Therapy and Anti-aging
Manoj Gupta1* and Jaishriram Rathored2*
This study reviews hyperbaric oxygen therapy's potential in regenerative medicine and anti-aging treatments.
Hyperbaric Oxygen Therapy (HBOT)
- HBOT uses 100% oxygen at high pressure for clinical applications.
- Effective for wound healing, burns, tissue necrosis, and other disorders.
- Physiological effects include increased tissue oxygenation and improved oxygen bioavailability.
- Current applications are limited due to unclear underlying mechanisms.
Regenerative Medicine
- Focuses on repairing or replenishing damaged tissues.
- Involves methods like tissue engineering and stem cell therapy.
- Regeneration varies by tissue type and declines with age.
- Environmental and genetic factors influence individual regeneration capacity.
Biological Aging
- Aging is characterized by the decline in physiological functions and homeostasis.
- Theories of aging include programmed longevity and damage/error theories.
- Aging leads to increased oxidative damage, mutation rates, and tissue deterioration.
- Telomere shortening is a significant factor in cellular aging.
Physiological Changes with Aging
- Aging results in loss of muscle mass, bone density, and organ function.
- Common issues include osteoporosis, cardiovascular diseases, and immune system decline.
- Aging affects respiratory and renal functions, leading to decreased capacity.
- Digestive and endocrine systems also show age-related deterioration.
Aging and Regeneration
- Regenerative capacity decreases with age, influenced by systemic factors.
- Younger individuals have higher regenerative abilities due to increased growth factors.
- Serum from young animals can enhance muscle regeneration in older counterparts.
- Cellular injury activates regeneration processes, but these diminish with age.
HBOT and Aging
- HBOT shows promise in regenerative anti-aging medicine.
- It can modulate cellular senescence and telomere shortening.
- Studies indicate a 20% increase in telomere length in aging blood cells after HBOT.
- HBOT reduces the number of senescent cells by 10%–37%.
Mechanisms of HBOT
- HBOT induces hyperoxic conditions that activate signaling pathways and growth factors.
- It promotes angiogenesis and collagen production, aiding tissue regeneration.
- The hyperoxic-hypoxic paradox enhances protective mechanisms against oxidative stress.
- HBOT can improve cognitive functions and promote neuroplasticity.
Future Prospects of HBOT
- HBOT is approved for 14 clinical conditions, showing potential in regenerative medicine.
- It alters gene expression in nearly 40% of protein-coding genes.
- The therapy enhances immune response and extracellular matrix formation.
- Further research is needed to understand mechanisms and optimize HBOT applications.
All Resources on HBOT:
Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post‑COVID condition: randomized controlled trialHyperbaric Oxygen Therapy in Managing Minimally Invasive Aesthetic Procedure Complications: A Report of Three CasesHyperbaric Oxygen Therapy in Sports Musculoskeletal InjuriesA General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational OpportunitiesPost-COVID-19 fatigue: A systematic reviewTherapeutic Effects of Hyperbaric Oxygen: Integrated ReviewTranscutaneous oxygen tension-guided hyperbaric oxygen therapy for preventing skin necrosis after hyaluronic acid filler injectionsHyperbaric Oxygen – Its Mechanisms and EfficacyHyperbaric Oxygen Therapy: Future Prospects in Regenerative Therapy and Anti-AgingHyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative StressHyperbaric Oxygen Therapy: Antimicrobial Mechanisms and Clinical Application for InfectionsEffects of Hyperbaric Oxygen Therapy on Long COVID : A Systematic ReviewEffects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot StudyHyperbaric Oxygen Therapy to Reverse Skin AgingOur Mission
To empower individuals to live longer, healthier lives, while embracing a gradual, lifestyle-friendly approach. By bridging cutting-edge research with practical solutions, we aim to inspire a global community to take control of their aging journey—today, not tomorrow.
How Can We Help
At Artisan Regenerative Centre, we offer a proactive approach to aging, focusing on science-based therapies that align with your lifestyle. Whether you’re looking for a gradual, less invasive path or exploring cutting-edge solutions, we can help you take the right steps toward better health and longevity.
