Benefits of HBOT:

1. Longevity

HBOT can induce a range of cellular, biochemical, and physiological changes, potentially promoting healthy aging. Some key benefits include:

• Enhancing Angiogenesis: HBOT supports the formation of new blood vessels.
• Reducing Inflammation: It regulates the number and activity of various inflammatory cell types.
• Enhancing Antioxidant Defenses: HBOT helps balance free radicals and scavengers.
• Counteracting Cellular Senescence: It may inhibit telomere shortening, a significant trigger for cellular aging.
• Increasing Stem Cell Circulation: HBOT stimulates the mobilization of stem cells and promotes their proliferation and differentiation.

Telomeres, the protective caps at the end of chromosomes, are essential for cellular division. With each cell division, telomeres shorten, and when they become too short, cells can no longer divide successfully. HBOT has been shown to lengthen telomeres by up to 38%, making it more effective than any current lifestyle modifications. Additionally, HBOT has been proven to decrease the presence of old cells by 11-37%, fostering regeneration of new cells, thus helping to reverse aging.

Oxygen therapy also provides relief from both acute and chronic pain and enhances sleep quality by promoting cell regeneration and increasing internal melatonin production, while improving blood flow. Furthermore, oxygen is non-toxic, non-invasive, and free from side effects.

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2. Sleep

The Cocoon by O2genes is a Hyperbaric Oxygen Chamber (mHBOT) that increases oxygen levels and pressure by 40%-50% above sea level. This wellness tool ensures the circulation of oxygenated blood throughout the body. In high-pressure oxygen environments, tissues receive a boost of oxygen, leading to benefits such as increased metabolism, enhanced energy levels, faster recovery, and more.

Exposure to elevated oxygen levels encourages the brain to enter deep, restorative sleep. Deep sleep is crucial for recovery and memory consolidation. In contrast, lower oxygen levels keep the brain in rapid eye movement (REM) sleep. HBOT can enhance deep sleep, benefiting individuals suffering from insomnia by ensuring they receive adequate restorative and slow-wave sleep.

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3. Fertility

HBOT significantly increases oxygen levels in the blood, which improves the functioning of the body by stimulating the development of new blood vessels (angiogenesis) and regulating oxidative stress. This oxygen-rich environment helps create optimal conditions for fertilization and enhances the effectiveness of assisted fertility treatments.

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4. Sports Recovery

HBOT can accelerate the return to pre-injury activity levels and improve the short- and long-term prognosis of injuries. Research has shown that HBOT reduces post-injury swelling in both animals and humans. It has also been associated with enhanced tissue remodeling after injuries, particularly in bones, muscles, and ligaments, which accelerates recovery. For example, during the Nagano Winter Olympics, athletes experiencing fatigue used HBOT, which helped them continue performing at their peak (Ishii et al., 2005).

HBOT has been shown to accelerate cell recovery and tissue repair, aiding in the elimination of fatigue and the restoration of stamina. Recent studies suggest that exposure to HBOT may also alleviate pain over both short and long periods.

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5. Cognitive Ability

Some case studies suggest that low-pressure HBOT can improve symptoms in children with autism by increasing oxygenation in underperfused areas of the brain. This treatment helps reduce neuroinflammation, oxidative stress, or a combination of both. Studies have shown that HBOT at pressures commonly used for children with autism (up to 1.5 atm/100% oxygen) improves cerebral perfusion, reduces inflammation, and does not worsen oxidative stress. Several studies on children with autism have reported improvements in various behavioral domains.

Overall, HBOT for children with autism appears to be safe, well-tolerated, and potentially effective. However, further research is needed to confirm its efficacy.

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6. Reduces Inflammation

Hyperbaric Oxygen Therapy (HBOT) reduces inflammation by increasing oxygen levels in tissues, which helps suppress pro-inflammatory cytokines (like TNF-α and IL-6), boosts anti-inflammatory signals (like IL-10), and enhances the body's antioxidant defenses. It also improves blood flow, reduces immune cell overactivation, and stabilizes blood vessels, all of which help calm chronic skin inflammation in conditions like eczema.

Conditions that benefits from HBOT:

• Depression
• Diabetes
• Musculoskeletal injuries
• Sports injuries
• Insomnia
• Non healing ulcers
• Post COVID19 symptoms
• Post stroke cognitive recovery
• Eczema

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The most measured man in the world, Bryan Johnson, reveals his results from 90 days of hyperbaric oxygen therapy.

Bryan Johnson’s Hyperbaric Oxygen Therapy Results: What He Found After 60 Sessions

Bryan Johnson, a venture capitalist famous for investing millions into age-reversal technologies, recently shared the results of undergoing 60 sessions of hyperbaric oxygen therapy (HBOT). Best known for its use in treating decompression sickness in divers, HBOT is also FDA-approved for various medical conditions like vision loss, hearing loss, and wound healing. However, its potential as an anti-aging therapy remains under investigation.

HBOT involves breathing pure oxygen in a pressurized chamber, increasing oxygen levels in blood and tissue. Johnson, who frequently monitors his biological age markers, used his rigorous data tracking to evaluate the impact of HBOT on aging-related metrics—and the results, according to him, were impressive.

The Protocol

Over a 90-day period, Johnson completed 60 HBOT sessions using a hardshell chamber pressurized to 2 atmospheres. Each session lasted 90 minutes, during which he alternated between breathing 100% oxygen for 20 minutes and taking 5-minute breaks. He reported these sessions delivered significant improvements across multiple health indicators.

“HBOT ranks as one of the highest value health therapies I’ve done,” Johnson shared on X.

Key Improvements Reported

1. Inflammation

Johnson reported that HBOT completely eliminated systemic inflammation in his body. His high-sensitivity C-reactive protein (hsCRP) levels fell below detectable limits. In addition, his C-reactive protein metabolite (CRPm) levels ranked in the lowest 1% of individuals tested—suggesting a powerful anti-inflammatory effect.

2. Muscle Oxygen Utilization

HBOT is known to improve blood vessel formation (angiogenesis). Johnson’s vascular endothelial growth factor (VEGF) levels rose by 300%, supporting increased vascularization. Additionally, skeletal muscle oxygen saturation (SmO₂) more than doubled during exercise at 210 watts after 40 sessions.

3. Telomerase Activity

Telomeres—protective caps at the end of chromosomes—shorten with age. Johnson found that HBOT boosted his telomerase activity to 7.7%, a level comparable to that of a 12-year-old. While his telomere length data was compromised by a lab error, he plans to retest and share those results later.

4. Gut Health

HBOT led to a 250% increase in short-chain fatty acids (SCFAs) and a 290% rise in n-butyrate levels—both essential for gut and metabolic health. Notably, the presence of Akkermansia muciniphila, a beneficial gut bacterium linked to strong intestinal barriers and metabolic balance, rose by 1000%.

5. Brain Aging

In Alzheimer’s disease, elevated tau protein levels in the brain are associated with inflammation and cognitive decline. Johnson’s phosphorylated tau (TAU127) dropped by 28.6%, from 0.14 pg/mL to 0.1 pg/mL, a level well below the Alzheimer’s risk threshold (0.18 pg/mL). This suggests a reversal of brain aging biomarkers.

6. Skin Aging

Johnson reported a reduction in his skin’s biological age from 39 to 38, based on skin texture, pore size, pigmentation, and other metrics. He also cited studies showing HBOT can increase collagen, blood flow, and reduce skin-cell senescence.

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“The outcomes match what we observed in the scientific literature and what we predicted in deciding to do this therapy. What’s notable is that after achieving elite level biomarkers over the past four years, my team and I have struggled to find new therapies that meaningfully improve my biomarkers. HBOT achieved that,” said Johnson.

Scientific Alignment

Johnson emphasized that the outcomes of his self-experiment align closely with existing scientific literature on HBOT. Given that he had already optimized many of his health markers over the past four years, he was surprised to find HBOT delivering additional meaningful improvements.

“After achieving elite-level biomarkers... HBOT achieved that,” he wrote.

A Free Alternative: Slow Breathing

For those unable to afford HBOT, Johnson and researchers suggest an alternative: conscious breathing techniques that activate the parasympathetic nervous system. This system regulates inflammation and oxidative stress—key drivers of aging.

A study by Gerbarg and Brown (2016) recommends breathing at a rate of 4.5–6 breaths per minute to balance the autonomic nervous system and promote calm alertness. Breathing even slower (3 or fewer breaths per minute) can induce a meditative, deeply restorative state.

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View original article here

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Other Resources

Understanding Hyperbaric Oxygen Therapy: Key Facts Explained

6 Reasons Why Top Athletes Use Hyperbaric Oxygen Therapy (HBOT)

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