Artisan NMN Nasal Spray Kit

Why NAD+ Matters?

NAD+(nicotinamide adenine dinucleotide) is a widely present coenzyme in organisms, playing a crucial role in cellular metabolism. NAD+exists in all living cells and participates in various biochemical processes. The main functions of NAD+include energy production, DNA repair, and activation of longevity genes. Due to the importance of NAD+and its decreasing trend with age, some studies are exploring the possibility of supplementing NAD * precursors such as NMN (nicotinamide mononucleotide) or NR (nicotinamide ribose) to increase NAD+levels in the body, thereby activating anti-aging related pathways such as the SIRT protein family, as a potential anti-aging strategy.

• NAD+ decreases with age, peaking in the teens.
• It turns out that NAD+ plays an important role in DNA repair and preventing aging.

→ The lack of NAD+ in the body will not only lead to rapid aging, but also one of the causes of lifestyle diseases such as diabetes.

Activation of Sirtuin Gene By NAD+

• The sirtuin gene is also known as a longevity gene or anti-aging gene.
• The sirtuin gene is closely related to aging and lifespan.
• According to research, activating the sirtuin gene can prolong the lifespan of organisms.
• Activating the sirtuin gene can improve and restore bodily functions such as repairing skin cells, enhancing physical strength, and relieving fatigue.

How is NAD+ synthesized?

There are two main mechanisms for the synthesis of NAD+ in the human body. One is the natural synthesis pathway De Novo pathway/canine urea pathway, in which NAD+ is synthesized from tryptophan (an essential amino acid). In this pathway, tryptophan undergoes oxidative cleavage to produce formylkynurenine. Tryptophan -2,3-oxygenase (TDO) and indoleamine-2,3-dioxidase (1D0) promote this process. The second pathway for synthesizing NAD+ is called the salvage pathway (Nam salvage pathway). The reason why it is named the salvage pathway is because when niacin, nicotinate adenine mononucleotide, and nicotinamide are consumed, NAD+ is recycled, hence the name. Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide adenine mononucleotide (NMN), which is then converted to another NAD enzyme, nicotinamide adenine transferase (Nmnat). In addition, niacin can be used as a precursor for synthesizing NAD+, producing nicotinate mononucleotide (NAMN), which can be converted to NAD+ by Nampt enzyme. The diversity of NAD+ synthesis pathways indicates the importance of NAD+ for the human body.

As mentioned earlier, NAD+ plays a crucial role in all major processes in the human body, so it is necessary to maintain NAD+ levels at optimal levels. Like pellagra, when symptoms of NAD+ deficiency such as dermatitis, dementia, and diarrhea occur, intravenous injection of NAD+ may be necessary. In addition to symptoms of NAD+ deficiency, there are also some reasons why individuals may consider receiving intravenous injections of NAD+. Some of the reasons are as follows:

1) Addiction Therapy

One of the most common reasons for considering intravenous injection of NAD+ is addiction treatment; Intravenous injection of NAD+ is effective for patients attempting to quit opioid, alcohol, chemical, and prescription drug addiction, and can also minimize the severity of withdrawal symptoms. The mechanism of action of NAD+ is still under study, but it is believed that intravenous injection of NAD+ can help clear drugs and reduce addictive desires.

2) Improve Cognitive Function

As mentioned above, NAD+ has protective and stimulating effects on the brain. Therefore, intravenous injection of NAD+ is expected to improve memory, enhance attention, promote brain regeneration, and improve overall neurological function. The exact way in which exogenous NAD+ supplements exert these effects is still under investigation.

3) Relieve Chronic Fatigue

Intravenous injection of NAD+ can be used to treat patients with chronic fatigue and lack of energy. NAD+ is an indispensable cofactor in the glycolysis and tricarboxylic acid systems, andthe adenosine triphosphate (ATP) produced by these pathways is the energy source of the human body. Supplementing with exogenous NAD+ is expected to increase ATP levels in the body, thereby increasing energy levels and reducing fatigue.

4) Enhance Athletic Ability

NAD+ participates in the generation of ATP, so athletes also receive intravenous injections of NAD+ to improve their athletic performance and results; NAD+ intravenous injection can increase the energy level, promote cognition, and improve reaction speed of competitive athletes. In addition, studies have shown that supplementing NAD+ can help with muscle repair and development, assist in muscle enlargement and muscle generation.

5) Pain Management

A new reason for intravenous injection of NAD+ is pain treatment. As is well known, NAD+ has significant anti-inflammatory effects in the body and is expected to alleviate pain by reducing inflammation associated with pain. The research on controlling pain by supplementing NAD+ is still ongoing, and there are no definite results so far.

6) Cardiovascular Function

The heart beats constantly and is the most metabolically active organ in the human body. Research has shown that normal NAD+ levels are crucial for maintaining the metabolic activity of the heart. In addition, normal levels of NAD+ are said to aid in post injury recovery in the event of severe heart disease, such as transient ischemic attacks or myocardial embolism. Other studies have shown that a lack of NAD+ can lead to heart diseases such as cardiac hypertrophy and fibrosis.

7) Renal Function

Generally speaking, kidney function decreases with age. Research has shown that supplementing NAD+ can enhance the preventive effect on acute kidney injury. In addition, supplementing NAD+ can promote the release of prostaglandin E2, which plays a role in improving renal function after acute kidney injury.

8) Liver Function

Normal NAD+ levels in the body are crucial for optimizing liver function; Some enzymes in the NAD+ pathway have been shown to prevent liver fibrosis. Research has shown that supplementing NAD+ can improve overall liver health, protect the liver from toxic diseases, and enhance the regenerative capacity of the liver after damage. These research results have also been published in papers.

9) Nervous Function

It has been proven that NAD+ and its precursors have a protective effect on brain neurons after severe neurological events such as stroke. The normal level of NAD+ in the body is crucial for the normal function and survival of brain neurons. In addition, supplementing NAD+ has been shown to be effective in treating and preventing certain neurodegenerative diseases, such as Alzheimer's disease, although these conclusions have not yet been established, there are still multiple studies exploring this possibility.

Difference between NAD+ and NMN

NAD+ (nicotinamide adenine dinucleotide) and NMN (B-nicotinamide mononucleotide) play different roles in organisms, and there is a direct precursor product relationship between them. In Japan, NMN drip is a hot topic in anti-aging. NMN is a precursor substance of NAD + , which generates NAD+ through biotransformation pathways. NAD+ drip therapy is very common in the United States. By using NAD+ drip therapy, direct injection of NAD+ components into the body can quickly reach various parts of the body.

Clinical Research on Liposomal NMN

In a double-blind, placebo-controlled study involving healthy adults, participants receiving liposomal NMN experienced a significant increase in blood NAD+ levels after four weeks of supplementation. The liposomal NMN group demonstrated an 84% increase in NAD+ levels and outperformed both standard NMN and placebo groups.

Why Choose NMN Nasal Spray?

Our NMN Nasal Spray offers a convenient alternative delivery method for individuals seeking to support their NAD+ levels.

Potential benefits of maintaining healthy NAD+ levels may include:

• Cellular energy support
• Healthy aging support
• Cognitive wellness support
• Physical vitality and endurance
• Cellular repair and maintenance

Research into NMN continues to grow, with early studies suggesting its potential role in supporting metabolic health, physical performance, and overall cellular function.

The Science Behind NAD+ Support

Scientific research has demonstrated that NMN supplementation can significantly increase NAD+ levels in the body. Maintaining healthy NAD+ levels is associated with cellular energy production, metabolic health, and healthy aging processes.

While research is ongoing, NMN remains one of the most extensively studied NAD+ precursors available today.

How can I increase my NMN naturally?

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Also found in small amounts in milk, cucumbers, and edamame.

NAD+, NMN, and NR — What's the Difference?

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Because NMN is one metabolic step closer to NAD+ than NR, many researchers consider it one of the most promising NAD+ precursors currently available. The Artisan NMN Nasal Spray leverages this efficiency while adding the advantage of direct brain-targeted delivery.

Safety & Dosage

• Doses up to 1,200 mg/day appear safe in humans
• Most studied benefits seen at 250–900 mg/day
• Well-tolerated with minimal reported side effects
• Always consult a doctor before starting

Quality You Can Trust

Our NMN Nasal Spray is produced using high-quality ingredients and rigorous quality control standards.

Made in Japan, every batch is manufactured with attention to purity, consistency, and safety, giving you confidence in the product you use daily.

Directions for Use

Activation Instructions

1. Pour the supplied diluent into the NMN lyophilized powder.
2. Shake thoroughly for 30 seconds until fully dissolved.
3. Transfer the activated NMN solution into the nasal spray bottle.
4. Secure the spray nozzle before use.

Suggested Usage

• 1–2 sprays per nostril in the morning
• 1–2 sprays per nostril in the afternoon
• Avoid use in the evening as some individuals may experience difficulty sleeping
• Consistent use for 3–4 weeks is recommended for optimal results